Ira Gerhardt
نویسنده
چکیده
منابع مشابه
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B cells migrate from the pleural space to the lung parenchyma to secrete polyreactive emergency immunoglobulin M (IgM). The process requir...
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BACKGROUND Atherosclerotic lesions grow via the accumulation of leukocytes and oxidized lipoproteins in the vessel wall. Leukocytes can attenuate or augment atherosclerosis through the release of cytokines, chemokines, and other mediators. Deciphering how leukocytes develop, oppose, and complement each other's function and shape the course of disease can illuminate our understanding of atherosc...
متن کاملModelling and simulating non-stationary arrival processes to facilitate analysis
This paper introduces a method to model and simulate non-stationary, non-renewal arrival processes that depends only on the analyst setting intuitive and easily controllable parameters. Thus, it is suitable for assessing the impact of non-stationary, non-exponential, and non-independent arrivals on simulated performance when they are suspected. A specific implementation of the method is also de...
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Providing probabilistic analysis of queueing models can be difficult when the input distributions are non-Markovian. In response, a plethora of methods have been developed to approximate a general renewal process by a process with the time between renewals being distributed as a phase type random variable, which allows the resulting queueing models to become analytically or numerically tractabl...
متن کاملTransforming Renewal Processes for Simulation of Nonstationary Arrival Processes
Simulation models of real-life systems often assume stationary (homogeneous) Poisson arrivals. Therefore, when nonstationary arrival processes are required it is natural to assume Poisson arrivals with a time-varying arrival rate. For many systems, however, this provides an inaccurate representation of the arrival process which is either more or less variable than Poisson. In this paper we exte...
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